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August 1959

Correlation Between in Vitro Studies and Response to Antibiotic Therapy in Staphylococcic Bacteremia

Author Affiliations


From the Infectious Disease Control Unit of the Department of Medicine of Marquette University School of Medicine and the Milwaukee County Hospital. Research Associate (Dr. Abboud) and Assistant Clinical Professor (Dr. Waisbren), Marquette University School of Medicine.

AMA Arch Intern Med. 1959;104(2):226-233. doi:10.1001/archinte.1959.00270080052006

The selection of the proper antibiotic is a major problem that faces the clinician who makes the diagnosis of Staphylococcus pyogenes var. aureus bacteremia. The present study was done to determine how helpful the tube-dilution method of determining bacterial sensitivity to antibiotics was in solving this problem.

In vitro antibiotic sensitivity tests have been criticized as inadequate because of the different milieu in which the antibiotic must act in vivo.1,2 Despite this criticism, many physicians are greatly influenced by the results of commercial disk antibiotic-sensitivity tests that are used in most bacteriology laboratories.3,4 Previous reports have stressed the lack of standardization of the disk method in testing antibiotic sensitivity of bacterial strains, and there was striking variability in the results reported from different laboratories.5-8 "False resistance" in many tests has been related to the rates of diffusion and deterioration of the antibiotic and has deprived patients of

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