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August 1959

Klinische Enzymologie: Die Fermente in der Pathogenese, Diagnostik und Therapie.

AMA Arch Intern Med. 1959;104(2):341. doi:10.1001/archinte.1959.00270080167025

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The author presents a survey of the rapidly growing field of clinical application of enzymology and succeeds well in his endeavor to "stimulate interest in what is probably the most fascinating field of research in modern medicine." In the introductory chapter, the basic precepts of enzymology are presented for the nonspecialist in succinct, but clear, fashion. This leads into the main part of the book, a thorough discussion of about thirty mammalian enzymes, which have been connected in some way with clinical findings or therapy. For each enzyme, the reaction catalyzed is presented, the occurrence and physiological properties are summarized, and pertinent effects of drugs and methods of assay are described briefly. The literature dealing with the association of the enzyme and disease states is discussed in detail and critically assessed. The value of determining a quantitative enzymatic pattern as a diagnostic tool is pointed out. It is regrettable that

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