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November 1959

Amyloid Nephrosis in Hodgkin's Disease: Presentation of a Case and Review of the Literature

Author Affiliations


From the medical service, Veterans Administration Hospital. Junior Resident in Medicine (Dr. Winawer) and Senior Resident in Medicine (Dr. Feldman).

AMA Arch Intern Med. 1959;104(5):793-796. doi:10.1001/archinte.1959.00270110113015

Although Hodgkin's disease and the nephrotic syndrome secondary to amyloidosis are not uncommon individual entities, their association in the same patient is rare. When this association does occur, it is usual for the nephrotic syndrome to appear after the picture of Hodgkin's disease is well established. For the reverse to occur is rare and warrants adding the present case to those previously reported.

The subject of amyloidosis in Hodgkin's disease was extensively reviewed by Wallace et al., in 1950. They discussed 29 previously reported cases of Hodgkin's disease and amyloidosis and added one case of their own, which presented with nephrosis. Although in all of their cases the association was present, only four presented with the nephrotic syndrome. Since this report, the literature was carefully searched for cases of nephrotic syndrome due to secondary amyloidosis in Hodgkin's disease and a total of nine additional cases 1-6 were found, six of

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