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Advances in the understanding of allergy have proceeded with giant strides in the last few years. Some of the most important paths of progress are described fully in this volume, by masters of their particular fields and with full bibliographic references. The significance and advances obtained in immunology with various techniques of gel diffusion are described by Ouchterlony, the father of this principle. Paton of London brings our knowledge of histamine and its localization, release by various mechanisms, and its depletion up-to-date. The mechanism of hemolysis by antibody and complement is discussed by Manfred Mayer. Boyden presents a full coverage of the various immunological responses claimed for antigens of the tubercle bacillus. The subject of immediate antigen-antibody reactions in the skin of experimental animals, including passive cutaneous anaphylaxis, is amply covered by its chief proponent, Ovary. Byron Waksman's chapter of more than one hundred pages covers a variety of basic