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February 1960

Macroglobulinemia Secondary to a Lymphosarcoma of the Brain

Author Affiliations


From the Department of Internal Medicine, University Hospital, University of Minnesota.

AMA Arch Intern Med. 1960;105(2):316-319. doi:10.1001/archinte.1960.00270140138016

Macroglobulinemia is a rare disease first described by Waldenström,1 in 1948. In North America Long et al.,2 in 1955, reported the first case, and since then a few more have been described.3-7 The disease is of unknown etiology.

We studied a patient with macroglobulinemia associated with lymphosarcoma of the brain. The latter was removed, after which the macroglobulins disappeared. Since the case is of unusual interest and throws light on possible relationship between the lymphosarcoma and macroglobulinemia, it is believed to be worthy of report.

Report of Case  A 63-year-old white woman was first seen at the University Hospital on June 13, 1955, with the chief complaints of weakness, anorexia, palpitation, and weight loss of three years' duration. Since 1954, she was followed by her local physician for anemia unresponsive to vitamin B12, liver extract, and iron. She had received multiple transfusions. She had suffered from typhoid

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