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February 1960

Chemical Quantitation of Epinephrine and Norepinephrine in Plasma.

Author Affiliations

By William Muir Manger, B.S., M.D., Ph.D. Price, $11.50. Pp. 398, with 68 illustrations. Charles C Thomas, Publisher, 301-327 E. Lawrence Ave., Springfield, Ill., 1959.

AMA Arch Intern Med. 1960;105(2):345. doi:10.1001/archinte.1960.00270140167026

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The measurement of the circulating blood level of all the known hormones is a cherished goal of biologists generally and of clinicians particularly. Through the pioneering work of von Euler, Lund, and Weil-Malherbe, it is now possible to determine the blood levels of epinephrine and norepinephrine by specific and sensitive chemical methods. The recent rapid growth of literature dealing with the pressor amines is in no small measure due to the consequent independence of bioassay procedures. Although the chemical procedures have been fairly well established, they still require a high level of skill and a painstaking attention to detail. Setting up these methods is still a formidable task.

The first chapter of this book presents an exhaustive review of available chemical methodology, well documented by comparative data from the author's experience. Forceful arguments are then made for the final choice of a modified Weil-Malherbe procedure. The discussion includes detailed plans

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