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April 1960

Peptic Ulcer and Hyperparathyroidism: A Survey of 300 Ulcer Patients

Author Affiliations


From the Divisions of General Medicine and Gastroenterology, Henry Ford Hospital, Associate Physician, Medical Service (Dr. Frame); Associate Physician, Division of Gastroenterology (Dr. Haubrich).

AMA Arch Intern Med. 1960;105(4):536-541. doi:10.1001/archinte.1960.00270160034006

"It is tempting to propose that careful screening of patients with peptic ulcer for hyperparathyroidism would yield cases of hyperparathyroidism which are not being recognized at present."

With these words Marden Black in his monograph 1 remarked the unusual frequency with which peptic ulcer disease is encountered among patients exhibiting hyperparathyroidism.2 Clinical evidence compels one to consider that this frequency may be greater than that expected by chance alone.3 Laboratory data suggest that a real, although undefined, influence is exerted by parathyroid hormone on gastric acid secretion 4 and on the gastrointestinal mucosa.5 Although Culver and St. Goar6 (and later Black himself7) have doubted the justifiable yield of surveying peptic ulcer patients for hyperparathyroidism, it occurred to us that the fertility of the field should be tested. The purpose of this paper is to report the results of such a survey and to comment on the difficulties encountered in studying

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