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April 1960

Antimicrobial-Steroid Treatment of Active Pulmonary Tuberculosis as a Routine Measure

Author Affiliations

Mount Vernon, N.Y.

From the Nathan B. Van Etten Hospital of the Bronx Municipal Hospital Center, New York, and the Division of Tuberculosis and Chest Diseases, Grasslands Hospital, Valhalla, N.Y.

AMA Arch Intern Med. 1960;105(4):542-559. doi:10.1001/archinte.1960.00270160040007

Introduction  Since the introduction of corticosteroid preparations in 1950, many contributions in the American, and particularly in the foreign literature, have dealt with the effect of these compounds on tuberculosis. Some of the pertinent papers have recently been reviewed by Des Prez and Organick.1 The communications can be divided, roughly, into several periods. The first, from 1950 to 1953, dealt with (a) the temporary beneficial effects of steroid hormones on patients severely ill with pulmonary tuberculosis,2 (b) the deleterious effect of steroid hormones in experimental tuberculosis,3,4 (c) the untoward effects of steroid hormones on existing tuberculosis,5 and (d) the occurrence of serious tuberculosis, often miliary, in patients not previously ill with the disease, who were under treatment with steroids for other conditions.6In 1953, and in subsequent years, there began to appear articles on the beneficial effects of steroid hormone therapy in conjunction with antimicrobial therapy in the treatment of

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