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April 1960

Chemistry of Pancreatic Diseases.

AMA Arch Intern Med. 1960;105(4):661. doi:10.1001/archinte.1960.00270160159023

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Progress in understanding the disease mechanisms in almost any tissue of the body is becoming more and more dependent on knowledge of intracellular metabolic processes in health and disease. Too often, however, the clinician and biochemist follow independent lines of investigation with insufficient exchange of ideas and knowledge. In his contribution to the American Lecture Series, Dr. Busch attempts to bridge this gap as far as the pancreas is concerned. He has summarized and interpreted the progress in basic biochemistry in such fields as the use of the electron microscope and isotopelabeled amino acids in the study of the zymogen granules. To those of us who have difficulty in understanding the original biochemical papers, even when we have time to read them, the first two chapters of this book are of immense value. The same applies to Dr. Busch's discussion of the mode of action of insulin and glucagon. His

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