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June 1960

I131 Triolein Tolerance Curves in Patients with Diabetes Mellitus: Their Similarity to Those Observed in Myocardial Infarction

Author Affiliations

Philadelphia With the Technical Assistance of Miss Jean Schraeder

From the Division of Cardiology, Philadelphia General Hospital.; Chief, Radioisotope Section (Dr. Sandberg); Resident (Dr. Min); Chief, Chemical Research Laboratory (Dr. Feinberg), Division of Cardiology, Philadelphia General Hospital. Director, Division of Cardiology, Philadelphia General Hospital, and Director, Division of Cardiovascular Disease, Graduate Hospital of the University of Pennsylvania (Dr. Bellet).

AMA Arch Intern Med. 1960;105(6):866-872. doi:10.1001/archinte.1960.00270180044006

When Thannhauser and Stanley1,2 fed I131-labeled olive oil and followed the appearance and disappearance of the radioactivity in the blood of their patients, they introduced a new, simple, and very valuable technique for the study of neutral fat metabolism in health and disease. Numerous reports soon followed3-6 in which I131-labeled neutral fat was used as a diagnostic tool in various malabsorptive syndromes. The fruitfulness of this field of investigation probably led to a delay in the use of this technique in studying hyperlipemic states, although the original workers reported abnormal curves in nephrotics and idiopathic hyperlipemia as well.1,2 Recent studies by others as well as in our laboratory 7-9 have demonstrated that individuals with proven myocardial infarction display elevated levels of blood radioactivity following ingestion of a radioactively labeled fat meal. Since it is well known that patients with diabetes mellitus have a tendency to develop atherosclerotic lesions at an

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