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After many years of experimentation and small-scale studies with various attenuated strains of poliovirus, followed by trials on successively larger numbers of persons with the strains that were finally selected, millions of human beings received oral poliovirus vaccines in 1958 and 1959 under a great variety of conditions in many different parts of the world. The questions now under lively discussion in the United States are whether the available data justify the conclusion that any such vaccine has been proved safe for those who receive it as well as for those who may become immunized by contact infection and whether such vaccines have been found to be sufficiently immunogenic to warrant their use in an attempt to eliminate the disease as well as the viruses that cause it. The fear that the vaccine strains may revert to a level of virulence comparable to that of naturally occurring paralytogenic polioviruses, already
Sabin AB. Oral, Live Poliovirus Vaccine for Elimination of Poliomyelitis. AMA Arch Intern Med. 1960;106(1):5–9. doi:10.1001/archinte.1960.03820010007003
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