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July 1960

Isolated Cryptococcosis Associated with Boeck's Sarcoid: Report of a Case Treated with Amphotericin B

Author Affiliations

Houston, Texas

From the Medical Service of Hermann Hospital and the Department of Medicine, Baylor University College of Medicine, Houston, Texas.

Arch Intern Med. 1960;106(1):101-111. doi:10.1001/archinte.1960.03820010103015

The association of cryptococcosis with diseases involving the reticuloendothelial system is well known. Of 243 cases of cryptococcosis reviewed by Collins, Gelhorn, and Trimble,1 51, or approximately 25%, were associated with the presence of Hodgkin's disease, lymphosarcoma, or leukemia. Many isolated reports exist in the literature relative to the development of disseminated cryptococcosis in patients with advanced malignant disease of all types. However, the coexistence of cryptococcal infection with Boeck's sarcoid has been encountered rather infrequently. Collins,2 in reviewing the subject of bone involvement in cryptococcosis, reported on three such cases, two of which were shown later to have had cryptococcosis alone. Gandy3 described a case of cutaneous cryptococcosis in a patient with proven sarcoidosis of several years' duration. Heller4 and others described a case of disseminated, nonmeningitic cryptococcal infection in a patient with well-documented preexisting Boeck's sarcoid. The first overt manifestation of the fungus infection in this case was