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July 1960

Irreversible Renal Failure Following Short-Term Therapy in Sarcoidosis

Arch Intern Med. 1960;106(1):112-116. doi:10.1001/archinte.1960.03820010114016

Hypercalcemia occurs in certain patients with sarcoidosis. The cause is not clearly defined. The studies of Henneman et al.1 suggest that the hypercalciuria of sarcoid may result from an excess endogenous source of vitamin D. Accordingly, sarcoid patients might exhibit unusual susceptibility to calciferol.

Curtis et al.,2 Robertson,3 and Nelson4 have shown that many patients with sarcoidosis are intolerant of large doses of vitamin D and, under such treatment, rapidly develop hypercalcemia. Harrell and Fischer5 reported one instance in which there was a rise in serum calcium from 9.6 to 14.2 mg. % when one pint of cod liver oil was ingested monthly.

This report presents a case of sarcoid in which irreversible renal damage occurred after administration of 1,200,000 units of vitamin D over an eight-day period. Ectopic calcification, renal calculi, and nephrocalcinosis appeared as complications. Steroid therapy was effective in reducing the ectopie calcium deposited, but there was

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