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Cirrhosis and hepatitis are diseases which have increased in frequency and for many years have played a larger and larger part in morbidity and mortality. Though this is a world-wide phenomenon, there is sufficient local variation in different parts of the world to make one suspect that our ideas of pathogenesis and of therapy must be seriously inadequate. Advances in clinical medicine usually come as a result of sound clinical observation which lead an investigator to the laboratory to explain some of the problems of the natural history of disease or particular difficulties he has encountered in sick patients. There is now an extensive clinical lore and a vast documentation that have to do with portal hypertension and its commonest cause, cirrhosis of the liver, and the most calamitous and often fatal complication, bleeding varices of the esophagus. Hunt and Liebowitz have approached this problem in radically different ways. Both
Bleeding Esophageal Varices: Portal Hypertension. AMA Arch Intern Med. 1960;106(1):156–157. doi:10.1001/archinte.1960.03820010158030
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