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August 1960

Amphotericin B Therapy in Torula Meningitis

Arch Intern Med. 1960;106(2):271-274. doi:10.1001/archinte.1960.03820020111016

The availability of the antifungal antibiotic amphotericin B necessitates its careful evaluation in the treatment of a heretofore uniformly fatal illness, torula meningitis. The recent past has seen other new and promising agents used, evaluated, and found to be wanting.1 Because central nervous system infections due to Cryptococcus neoformans may have long periods of spontaneous remission, final judgment of any specific therapy will have to await the test of time. However, if promising results are now obtained through the use of amphotericin B, physicians should be made aware so that no clinical case of torulosis goes untreated while the final data are being accumulated.

We are reporting this case of torula meningitis as an instance of the life-saving ability of amphotericin B. If the course of a steadily worsening illness is sharply and definitely reversed promptly after the beginning of a specific therapy, it behooves one to, at least,