The association of goiter with hypothyroidism in nonendemic areas has been noted with increasing frequency since 1943.1,2 Since the classic studies of Stanbury and Hedge in 1950 3 there have been many reports, and these have shed light on the nature of thyroid function and hormonopoiesis. An excellent review was published by Stanbury and McGirr in 1957.4
In March, 1956, there was presented the problem of an adolescent boy of subnormal intelligence with a rapidly enlarging goiter and unusual findings on routine tests of thyroid function.
Report of Case
A 141/2-year-old white, seventh-grade schoolboy was first seen on March 8, 1956, because of an enlarging thyroid gland. The family had been aware of a mass in the neck at least from age 3. He was thought by the parents to be the least intelligent of their seven children and had repeated two grades in school. Enuresis was a
DONALD W. CLARK, JOHN MILNE, ROBERT J. VANDERLINDE. Congenital Goiter with Monoiodotyrosine in the Serum. Arch Intern Med. 1960;106(2):275–279. doi:10.1001/archinte.1960.03820020115017