Since radioactive I131 was first introduced, various isotopic methods—all depending on the fact that I131 follows the same metabolic pathway as stable I127—have been tried for evaluation of thyroid activity. Those tests which have won widest acceptance are those with greatest simplicity of performance without sacrifice of accuracy and those in which the smallest possible amount of radioactive I131 was employed as a tracer dose but with sufficient iodine uptake for quantitative determination of thyroid function. With this in mind, the present study was undertaken to simplify an existing method without loss of accuracy and, at the same time, compare it with other methods enjoying wide use.Tests based on the iodide phase of iodine metabolism measure the capacity of the thyroid to trap iodine selectively from the plasma; these tests include the 24-hour uptake, shorter intervals uptake studies (e.g., two-hour and six-hour uptakes), thyroid iodide clearance, accumulation gradient,
GAGLIARDI RA, JOYRICH MH, FEIGELSON HH, SHUFRO AS. Neck-Thigh Ratios of I131 Activity. Arch Intern Med. 1960;106(3):407–409. doi:10.1001/archinte.1960.03820030095014
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