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Any comparison would probably be unfair if made between Gamble's Chemical Anatomy, Physiology and Pathology of Extracellular Fluid, a lecture syllabus published first in 1942, and the present syllabus published 17 years later. However, both were printed by the Harvard University Press with almost identical binding and format and both are products of members of the faculty of the Department of Pediatrics at Harvard. Each is a product of its time. Chemical Anatomy, as its name implies, is more fundamentally descriptive of fine details whereas Metabolic Homeostasis takes a broad view of the range, distribution and tolerance of, and effects of disease on, selected body constituents. In many respects the earlier syllabus or what it contains is a prerequisite to the latter.
Chemical Anatomy gave the extracellular fluid approach and the effect of changes in sodium content on distribution of body water was discussed in terms of mEq/liter. Metabolic Homeostasis
Mason EE. Metabolic Homeostasis: A Syllabus for Those Concerned with the Care of Patients. Arch Intern Med. 1960;106(5):739–741. doi:10.1001/archinte.1960.03820050151024
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