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December 1960

The Clinical Evaluation of Vancomycin in Treatment of Multiantibiotic Refractory Staphylococcal Infections: II. The Use of Vancomycin After Failure of Bactericidal Antibiotics

Author Affiliations


Department of Medicine, University of Miami School of Medicine and the Jackson Memorial Hospital, Miami, Fla. Assistant Professor of Medicine and Markle Scholar in Medical Science (Dr. Ehrenkranz): Instructor in Medicine (Dr. Cohen).

Arch Intern Med. 1960;106(6):842-851. doi:10.1001/archinte.1960.03820060094010

Vancomycin has been demonstrated to be an extremely effective antibiotic for the treatment of staphylococcal infections. Striking results have attended its use in staphylococcal bacteremia and endocarditis, clinical situations in which high mortality rates might otherwise be expected.1,2 The efficacy of vancomycin relative to other drugs is not yet fully known. In a previous report from this laboratory,3 vancomycin was found to be effective in the treatment of staphylococcal infections after bacteriostatic antibiotics, such as novobiocin, chloramphenicol, and erythromycin, in various combinations had failed. Moreover, evidence was obtained which indicated that vancomycin might be curative when other bactericidal drugs had been ineffective. The present study was undertaken to extend these observations by the use of vancomycin for the treatment of staphylococcal infections after therapy with another bactericidal antibiotic had proved unsuccessful. In order to approximate similar bacteriological conditions for comparative purposes, only those patients were selected for vancomycin