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December 1960

The Budd-Chiari Syndrome: Report of a Case

Author Affiliations

Upland, Calif.

From the San Antonio Community Hospital, Upland, Calif., Departments of Medicine (Dr. Gattas) and Pathology (Dr. Hall).

Arch Intern Med. 1960;106(6):852-858. doi:10.1001/archinte.1960.03820060104011

Introduction  Thrombosis of the hepatic veins was first described by Budd in 1845, at which time three cases were reported; two with liver abscesses and one with synechia cordis, perihepatitis, and peritonitis. In 1899 Chiari more completely described the syndrome, reporting three of his own cases and seven others that he had collected. In 1905 the first case was reported in America by Hess,1 who reviewed 23 previous cases. In 1915 Nishikawa published 10 cases, and in 1945 Kelsey and Comfort2 reported 20 cases occurring at the Mayo Clinic from 1910 to 1939. By 1952 there were 115 cases reported,3 and in 1959 Parker4 analyzed 164 cases, including 15 reported by him. He reviewed 29,720 necropsies at the London Hospital, finding 18 cases of occlusion of the hepatic veins (3 of which had been reported previously), an incidence of 0.061%. Armstrong and Carnes found only 5 cases in 11,979 autopsies