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December 1960

Löffler's Syndrome: Report of a Case Associated with the Administration of Aurothioglucose (Solganal)

Arch Intern Med. 1960;106(6):874-877. doi:10.1001/archinte.1960.03820060126015

Löffler 1 first reported the association of pulmonary infiltrations with blood eosinophilia in 1932. The original cases had mild symptoms and a short benign course. Since then, other cases of a severer nature have been described, and evidence has accumulated that supports or suggests the allergic nature of this syndrome. Welzer and Apt express the opinion that "Löffler's Syndrome is a state in the broad spectrum of sensitivity in which the main 'Shock Organ' happens to be the lungs."

The following case is of interest because of the very severe symptomatology that occurred during therapy with aurothioglucose (Solganal). As far as can be determined, no similar reaction to aurothioglucose has been reported. Of additional interest is the dramatic response to hydrocortisone.

Report of Case  This was the first St. Vincent's Hospital admission (Jan. 12, 1959) of a 56-year-old white married woman with the chief complaint of severe dyspnea and orthopnea