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January 1961

Study of Bacterial Endocarditis: Comparisons in Ninety-Five Cases

Author Affiliations


From the Division of Cardiology, Department of Medicine, The Mount Sinai Hospital.

Arch Intern Med. 1961;107(1):6-15. doi:10.1001/archinte.1961.03620010010004

In 1950 we reported our experience with 148 cases of bacterial endocarditis treated at The Mount Sinai Hospital in New York during the early penicillin era (1944-1950) and set up revised criteria for early diagnosis and effective treatment. The present report represents a comparative analysis of 95 subsequent cases of bacterial endocarditis in the light of these revised criteria, the availability of a greater variety of antibiotics, and improved methods of treatment.

Persistent shortcomings in therapeutic results are indicated by reports of a recovery rate approximately between 65% and 80% (Donzelot et al.,2 65% of 202 cases; Dormer,3 75% of 82 cases; Afremow,4 34.7% of 202 cases; Geraci,5 70% of 169 cases; Morgan and Bland,6 68% of 228 cases; Cummings et al.,7 58% of 55 cases). Geraci cites an improving cure rate up to 85% for patients with streptococcal and staphylococcal infection. In addition to

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