The clinician may find it convenient to classify brucellosis as bacteremic, serologic, localized, or mixed (Table 1). In the bacteremic type the essential of diagnosis is the culture of brucellar organisms from specimens of the blood; but also agglutination titers are usually high and frequently rising. Most victims of this type of the disease are acutely and severely ill.
The serologic type is identified by high— and preferably rising—agglutination titers in the serum of a patient having systemic manifestations compatible with the disease, but in which brucellar organisms are not obtainable from cultures of specimens of blood, and in which there is no lesion to examine histologically and bacteriologically.
In the localized type the essential of diagnosis is the culture of brucellar organisms from specific tissues of the victim, such as the lung, spleen, or kidney. In cases of this kind the process may have been present many years. Often
MARTIN WJ, NICHOLS DR, BEAHRS OH. Chronic Localized BrucellosisWith Recurrent Constitutional Manifestations. Arch Intern Med. 1961;107(1):75–80. doi:10.1001/archinte.1961.03620010079013
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