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February 1961

Some Heritable Causes of Gastrointestinal DiseaseSpecial Reference to Hemorrhage

Arch Intern Med. 1961;107(2):182-203. doi:10.1001/archinte.1961.03620020032004

Introduction  There is increasing awareness of the importance of heritable diseases in medical practice. Individually, most of the diseases with a clearly defined pattern of inheritance are rare, but as a group they make up an appreciable proportion of the cases with which we have to deal. Some of them affect the alimentary tract, and an awareness by the doctor of their manifestations and genetic implications is of importance in the management of the patient and his family. In other gastrointestinal diseases environmental factors are of major importance, and although genetic factors contribute, no clear pattern of inheritance is evident. Peptic ulceration22 and gastric cancer39 may be mentioned as examples of the latter group.The patient suffering from recurrent gastrointestinal bleeding of uncertain origin presents a perplexing problem, and the cases to be described will illustrate some of the distinctive features which may assist the internist when confronted

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