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March 1961

Primary Hyperparathyroidism: A Diagnostic Challenge

Author Affiliations


From the Medical Department, Henry Ford Hospital.

Arch Intern Med. 1961;107(3):361-371. doi:10.1001/archinte.1961.03620030049006

Despite the numerous articles and reviews that have appeared on the subject of hyperparathyroidism, the diagnosis of this condition continues to be frequently overlooked. The late diagnosis of hyperparathyroidism, after the appearance of cystic bone changes and multiple kidney stones, should be a thing of the past; there are numerous clinical clues that, when properly evaluated, should suggest the diagnosis early in the course of the disease. The role of serendipity in this diagnosis has been emphasized,1 but assumes less importance the more intimate knowledge one has with the disease.

In this article we attempt to outline an all-inclusive diagnostic approach to hyperparathyroidism. We will review our experience at the Henry Ford Hospital and correlate it with those of others as reported in the literature. From 1934 to 1959, there have been 21 proven cases of primary hyperparathyroidism at this hospital. This is a relatively small series when compared

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