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March 1961

Loffler's Syndrome Associated with Nickel Sensitivity

Author Affiliations


Jefferson Medical College.

Arch Intern Med. 1961;107(3):405-408. doi:10.1001/archinte.1961.03620030093014

The increasing prevalence of nickel sensitivity in recent years has been emphasized by many investigators.* Most of these investigators have directed attention primarily to the dermatologic manifestations of sensitization to nickel; however, it is noteworthy that other allergic phenomena may also be encountered. Within the past year Arvidsson and Bogg1 published a case report which indicated an association between Löffler's syndrome and acute nickel dermatitis. This publication has stimulated us to report a second case of Löffler's syndrome (pulmonary eosinophilia) in association -with severe nickel sensitivity.

Report of Case  The patient is a chemical engineer, aged 52 years, who was employed for several years in the design and development of an industrial plant manufacturing nickel carbonyl. The plant was constructed in a distant city in 1952, and during the first 6 months of the plant's operation, the patient was engaged in direct supervision of nickel carbonyl production. During these