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March 1961

The Chemistry of Thyroid Disease

Arch Intern Med. 1961;107(3):464. doi:10.1001/archinte.1961.03620030152027

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Modern diagnosis and treatment of thyroid diseases is utterly dependent upon a working knowledge of the chemistry of the thyroid hormones. Without such background the clinician cannot interpret the results of the newer functional tests, such as the level of protein-bound iodine in the blood serum or the thyroidal uptake of I131. Recent investigations have yielded the discovery of several causes for myxedema, delineated by tests stimulating the anterior pituitary or blocking various enzyme systems that participate in the synthesis of thyroxine. The physician will therefore welcome this well-ordered succinct presentation of present chemical knowledge, culled by experts in the field from the enormous and confusing literature on the subject.

The authors carefully selected for detailed discussion what they consider the best and most important work, avoiding ponderous review of many articles which seem, at present, to be unimportant. The result is 65 pages of text that telly a

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