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Article
April 1961

Ristocetin in Bacterial Endocarditis: An Evaluation of Short-Term Therapy

Author Affiliations

WASHINGTON, D.C.

From the Department of Medicine, The George Washington University School of Medicine and the George Washington University Medical Division, District of Columbia General Hospital, Washington, D.C.; Professor of Medicine, The George Washington University School of Medicine, and Chief, The George Washington University Medical Division, District of Columbia General Hospital (Dr. Romansky); Instructor in Medicine, The George Washington University School of Medicine (Dr. Foulke); Chief Resident, The George Washington University Medical Division, District of Columbia General Hospital (Dr. Olsson); formerly Chief Resident, The George Washington University Medical Division, District of Columbia General Hospital (Dr. Holmes).

Arch Intern Med. 1961;107(4):480-493. doi:10.1001/archinte.1961.03620040006002
Abstract

The discovery of penicillin and its use in the treatment of bacterial endocarditis was the first major advance in the management of this very serious disease. The demonstration that concurrent penicillin and streptomycin are usually more effective than penicillin alone accounted for the next therapeutic achievement. This combination, generally considered to be the most effective bactericidal therapy now available for penicillin-sensitive α-hemolytic streptococcal endocarditis, has shortened the duration of antimicrobial treatment for this entity. It has also proved to be significantly more effective for enterococcal endocarditis than penicillin alone. The third advance in the therapy of bacterial endocarditis was the successful short-term therapy of enterococcal endocarditis with ristocetin, first reported at the Antibiotic Symposium in 1957.1 This report revealed the adequacy of 14 days of therapy with ristocetin, and indicated a greater effectiveness than that achieved using penicillin and streptomycin for 6 or more weeks.

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