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April 1961

Fat Infusions: Toxic Effects and Alterations in Fasting Serum Lipids Following Prolonged Use

Author Affiliations


VA Clinical Investigator (Dr. Alexander).; Department of Medicine and Radioisotope Service, Veterans Administration Hospital, University of Minnesota.

Arch Intern Med. 1961;107(4):514-528. doi:10.1001/archinte.1961.03620040040005

During the past 10 years much effort has been directed toward developing a fat emulsion for intravenous use. These efforts have been hampered by the high incidence of side-effects occurring during the infusion itself or shortly thereafter.1-4 With the development of newer fat emulsions, such as cottonseed oil emulsion (Lipomul-I.V.; Upjohn Company), these acute side-effects associated with its administration have been reduced to an acceptable minimum,5-10 and its use has recently been recommended as a caloric supplement in situations where oral feeding is not adequate to meet requirements.8,9,14 Though many papers have dealt with the chronic effects of fat infusions, and much valuable information has resulted,5-13

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