This presentation has 2 major objectives. The first is to present an over-all analysis of the findings and experience of those who have studied primary aldosteronism with the hope that it will serve as a basis for improvement of diagnostic criteria of this curable form of hypertension. The second is to define and perhaps clarify current problems in distinguishing primary aldosteronism from renal, malignant, and essential hypertension.
The Figure shows a few data over 5 years on the first patient recognized as having primary aldosteronism.1-4 Of note are a 14.8 gm. right adrenal adenoma, very high values for aldosterone in the preoperative period with mild hypertension, the quick reversal of the abnormal electrolyte pattern of the serum in the postoperative period, the elevated levels of serum potassium 3 months after operation suggesting aldosterone deficiency, and finally, 5 years later, the maintenance of normal blood pressure, normal serum electrolytes, and
CONN JW. Aldosteronism and Hypertension: Primary Aldosteronism Versus Hypertensive Disease with Secondary Aldosteronism. Arch Intern Med. 1961;107(6):813–828. doi:10.1001/archinte.1961.03620060013005
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