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June 1961

Bullae in Systemic Lupus Erythematosus

Author Affiliations


Present address: Strangeways Research Laboratory, Cambridge, England (Dr. Weissmann).; From the Department of Medicine and the Study Group for Rheumatic Disease of the New York University School of Medicine and the Third (New York University) Medical Division, Bellevue Hospital.

Arch Intern Med. 1961;107(6):908-914. doi:10.1001/archinte.1961.03620060108013

While the transient appearance of vesicles in the skin of patients with systemic lupus erythematosus has been amply documented,1-6 little attention has been called to the occurrence of giant bullae as a manifestation of the disease. The classical lesion of systemic lupus in the skin is macular, erythematous, and only rarely leads to vesicle, bleb formation, or crusting.7 Indeed, while the mucous membrane lesions are felt perhaps to originate in vesicles,6 the skin ulcerations occasionally seen in patients with systemic lupus have rarely been attributed to such primary vesiculation.2 The occurrence of bullous lesions is noted in most large series of observations,2,4,6 but such lesions have not been reported to dominate the cutaneous manifestations in any given case. Recently we have seen 2 patients, in whose clinical picture giant bullae leading to ulceration and scarification were the predominant skin lesions.

Report of Cases 

Case 1.— 

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