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August 1961

Wegener's Granulomatosis: Report of Two Cases and Brief Review

Author Affiliations


Fellow in Medicine, Mayo Foundation (Dr. Kinney); Section of Medicine (Dr. Olsen, Dr. Hepper), Section of Surgical Pathology (Dr. Harrison), Mayo Clinic and Mayo Foundation. The Mayo Foundation, Rochester, Minn., is a part of the Graduate School of the University of Minnesota.

Arch Intern Med. 1961;108(2):269-278. doi:10.1001/archinte.1961.03620080101010

Wegener's granulomatosis is a rare disease of unknown cause that is characterized by necrotizing granulomas of the upper and lower parts of the respiratory tract, necrotizing angiitis, and focal necrotizing glomerulitis. Lesions also are found commonly in the spleen and, indeed, in almost any part of the body, including the heart. Although the condition was first described by Klinger,1 in 1931, it was not until 1936, when Wegener2 reported 3 cases, that the syndrome was recognized as a distinct clinical entity thought to be a variant of periarteritis nodosa. However, in contrast to the latter condition, the presence of hypertension, allergic manifestations, and eosinophilia is rare. After a review of the literature in 1958, Walton3 accepted 56 documented cases of Wegener's granulomatosis, which included his own. Blatt and associates4 reviewed the literature since 1897 and found reports of 112 cases of midline granuloma of the upper

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