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Sept 1961

Coxsackie Viral Infections

Author Affiliations

Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, Boston City Hospital, and Department of Medicine, Harvard Medical School, Boston, Mass.

Arch Intern Med. 1961;108(3):329-334. doi:10.1001/archinte.1961.03620090001001

The isolation by Dalldorf and Sickles1 of viruses, which produced paralysis with destructive lesions of muscle in suckling mice and hamsters, from the stools of two children with signs of paralytic poliomyelitis was an achievement that may rank in importance with Landsteiner and Popper's2 production of human poliomyelitis in monkeys. These viruses were first recovered in the laboratory of the New York State Department of Health from specimens collected in the village of Coxsackie on the banks of the Hudson River, but they were soon found to be world-wide in distribution and were officially named for their site of origin.3

Strains of Coxsackie virus were soon divided into 2 groups on the basis of the morbid anatomy that resulted from inoculation in suckling mice: those of Group A produced primarily lesions of skeletal muscle, whereas those of Group B also produced lesions in the central nervous system

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