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Sept 1961

Hepatic SarcoidosisCause of Portal Hypertension and Liver Failure; Review

Arch Intern Med. 1961;108(3):483-495. doi:10.1001/archinte.1961.03620090155017

The development of knowledge validating sarcoidosis as a distinct clinicopathologic entity has been traced and reviewed.* The purpose of this study is to review the incidence of hepatic sarcoidosis, its relationship to liver failure with jaundice, ascites, and portal hypertension, and to add to the literature 2 cases of portal hypertension and 2 cases of liver failure without portal hypertension, all secondary to intrinsic hepatic sarcoidosis.

Report of Cases 

Case 1.—  A 41-year-old Negro woman complained of abdominal distention, weight loss, and anorexia of 3 months' duration. Past history was negative for jaundice, liver disease, or alcoholism.Physical examination revealed scleral icterus, normal fundi, and no lymph node enlargement. The liver was palpated 8 cm. below the right costal margin, was firm and nontender. The spleen was felt 4 cm. below the left costal margin. A fluid wave and shifting dullness were demonstrated, and there was 1+ pitting edema of

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