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October 1961

Malignant Renal Hypertension: Twenty-Year Medical History

Author Affiliations


Department of Surgery (Urology) University of California Medical Center, Los Angeles (Dr. Winer).

Arch Intern Med. 1961;108(4):588-593. doi:10.1001/archinte.1961.03620100080011

Experimental research revealed the relationship of renal disease to hypertension1 and led clinicians to investigate cases of hypertension for unilateral renal lesions with the hope of restoring the blood pressure to normal by removal of the diseased kidney. Proof of cure requires long follow-up study because hypertension may temporarily recede after any surgery, only to become manifest at a later date. This case report is a 20-year medical history of severe malignant hypertension associated with hypertensive retinopathy and encephalopathy relieved by nephrectomy.

Report of a Case  At the age of 19 years, a white woman delivered a normal baby on March 24, 1939, after a normal pregnancy. The blood pressure at that time was 110 mm. Hg. systolic, and 70 mm. diastolic. Six weeks later she developed severe persistent headaches, tinnitus, visual difficulty, and a reported systolic blood pressure of "196." On May 11, 1939, after a severe headache,