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October 1961

Severe Herpes Zoster During Corticosteroid Therapy: Report of a Severe Attack in a Patient with Rheumatoid Arthritis

Author Affiliations


Arch Intern Med. 1961;108(4):594-598. doi:10.1001/archinte.1961.03620100086012

The recent reports of Weller and coworkers have clearly identified the causative viral agent of herpes zoster infection in man, and have emphasized the impressive evidence that a single virus is probably responsible for both varicella and herpes zoster infections.1,2

Advances in the therapy of zoster infections have not kept pace with these advances in our fundamental knowledge of the virus' properties. Epstein and Allington have reported the results of treating 251 patients with herpes zoster infections with one or combinations of the following agents: autohemotherapy, antibiotics, thiamine, posterior pituitary hormone injection (Pituitrin), x-ray, analgesics, corticosteroids, infrared lamp, vasodilators, sulfonamides, Protamide, and immune globulin.3 Regardless of the mode of therapy, the average course of the disease was found to be 2 to 3 weeks. Single or combination therapy with any of these agents failed to shorten the natural course of the disease. Their results clearly point out the

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