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October 1961

Alveolar Proteinosis

Author Affiliations


From Presbyterian Hospital, Allegheny General Hospital and from the Laboratory of Experimental Surgical Research, Department of Surgery, University of Pittsburgh Medical School.

Arch Intern Med. 1961;108(4):611-613. doi:10.1001/archinte.1961.03620100103015

A new pathological entity has appeared in the literature to which the name of pulmonary alveolar proteinosis has been applied. The typical lesion consists of a deposition of PAS-positive protein material which is present within the alveolar sacs and is not accompanied by extensive fibrosis of the surrounding lung parenchyma. This entity was first publicized by Rosen, Castelman, and Liebow with a review of 25 cases.1 Robin, Mars, and Gaensler2 have recently reported 6 cases and have described the pathophysiologic features associated with pulmonary alveolar proteinosis. The only other reports have been sporadic in number. The following case of this bizarre disease is affirmed.

Report of a Case  A 41-year-old white male was admitted to the Presbyterian Hospital on Aug. 8, 1958, because of recurrent chills, fever, cough, and hemoptysis over a period of 4 years. His illness originally began with an episode of "pneumonia" that lasted approximately

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