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November 1961

Megaloblastic Anemia in Association with Jejunal Diverticula

Author Affiliations


Residents in Medicine, Department of Medicine, Stanford University School of Medicine, San Francisco (Dr. Crawford and Dr. Freeman).

Arch Intern Med. 1961;108(5):775-780. doi:10.1001/archinte.1961.03620110115015

In 1930 Taylor described a case of jejunal diverticulosis associated with pernicious anemia.1 Since that time, macrocytic anemia with intestinal diverticula has been described in 18 additional cases.2-14 In 8 of these, gastric acid was demonstrated, thus essentially excluding Addisonian pernicious anemia. In 9 of the cases, achlorhydria or "nearly complete achlorhydria" was noted; in 2 reports, the presence of gastric acid was not mentioned13,14 (Table 1). This report describes another case of non-Addisonian megaloblastic anemia apparently due to small bowel diverticulosis.

Report of a Case  An 85-year-old retired white carpenter was admitted to Palo Alto-Stanford Hospital Center on Sept. 30, 1959, with the history of diarrhea and weight loss of 4 years' duration.

Present Illness.—  In 1955 he was seen by his physician because of a prolonged episode of diarrhea. At that time his red cell count was 4,400,000 per cu. mm., hematocrit was 43%, and

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