In 1930 Taylor described a case of jejunal diverticulosis associated with pernicious anemia.1 Since that time, macrocytic anemia with intestinal diverticula has been described in 18 additional cases.2-14 In 8 of these, gastric acid was demonstrated, thus essentially excluding Addisonian pernicious anemia. In 9 of the cases, achlorhydria or "nearly complete achlorhydria" was noted; in 2 reports, the presence of gastric acid was not mentioned13,14 (Table 1). This report describes another case of non-Addisonian megaloblastic anemia apparently due to small bowel diverticulosis.
Report of a Case
An 85-year-old retired white carpenter was admitted to Palo Alto-Stanford Hospital Center on Sept. 30, 1959, with the history of diarrhea and weight loss of 4 years' duration.
In 1955 he was seen by his physician because of a prolonged episode of diarrhea. At that time his red cell count was 4,400,000 per cu. mm., hematocrit was 43%, and
CRAWFORD DW, FREEMAN RM. Megaloblastic Anemia in Association with Jejunal Diverticula. Arch Intern Med. 1961;108(5):775–780. doi:10.1001/archinte.1961.03620110115015
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.