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November 1961

Chemistry and Therapy of Chronic Cardiovascular Disease

Arch Intern Med. 1961;108(5):811. doi:10.1001/archinte.1961.03620110151033

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The authors attempt, as indicated in the preface, to emphasize the position of chemistry in the understanding of the more recent advances in chronic cardiovascular disease. They select certain topics related to chemistry and therapy of chronic cardiovascular disease. The authors, without paying too much attention to chemistry of muscular contraction, myocardial metabolism, or other related topics, stress the problem of chemistry and therapy of chronic heart disease from a practical and applied point of view. In this they have succeeded very well. They discuss the various actions of digitalis and of oral diuretics; they deal with blood clotting mechanisms, anticoagulation, and finally atherosclerosis. It is in this last chapter that they have, in the reviewer's opinion, succeeded best, particularly when they review the mechanism of coronary occlusion. It is true that there are a large number of original articles and review articles which deal with this subject, but it

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