Recently, we have encountered a group of patients with aortic stenosis who present with recurrent, often massive, unexplained gastrointestinal hemorrhage. Our attention was directed to this association when 4 such patients were admitted to the Massachusetts General Hospital during a single 2-week interval. A study of this clinical association was undertaken by analysis of a large group of consecutive patients with gastrointestinal bleeding. Patients with obvious sources for bleeding were analyzed for associated aortic valvular disease and, in addition, patients with aortic stenosis proven at autopsy or occasionally left heart catheterization were studied with respect to history of gastro-intestinal hemorrhage. Heyde1 and Schwartz2 in 1958 have called attention previously to the association of gastrointestinal bleeding and aortic stenosis, but no other references to this were found in a review of the literature.
Plan of Study
The records of 1,782 consecutive patients, diagnosed as having gastrointestinal bleeding and admitted
WILLIAMS RC. Aortic Stenosis and Unexplained Gastrointestinal Bleeding. Arch Intern Med. 1961;108(6):859–863. doi:10.1001/archinte.1961.03620120043007
Artificial Intelligence Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.