[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Navigation Landing]
December 1961

Unilateral Pulmonary Arteriosclerosis: Unusual Fibrous Connective Tissue Growth Associated; Review of Literature and Discussion of Possible Physiological Mechanisms Involved in These Changes

Author Affiliations


Assistant Professor of Medicine, Department of Medicine, Western Reserve University and University Hospitals of Cleveland (Dr. Inkley); Fellow in Pathology, Western Reserve University, Institute of Pathology (Dr. Abbott).

Arch Intern Med. 1961;108(6):903-915. doi:10.1001/archinte.1961.03620120087012

An extensive fibrous connective tissue proliferation suggestive of retroperitoneal fibrosis or chronic mediastinitis is reported here. Aside from being the most extensive involvement that we can find after reviewing the literature, this lesion produced a most interesting natural experiment in the development of pulmonary arteriosclerosis. This change was unilateral and associated with complete obstruction of the pulmonary vein on the involved side. Although there have been several case reports of pulmonary vein obstruction in association with a similar lesion, none of these has been unilateral and unaccompanied by cor pulmonale.

Report of Case  His first admission was in 1951, at age 39, because of a history of hemoptysis which was of 9 years' duration. In 1942 he had gone to Arizona for several months following a period of heavy cough, mild hemoptysis, fever, and weight loss from which he made an uneventful recovery. Chest x-rays at that time are said