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December 1961

Chemistry of Drug Metabolism

Arch Intern Med. 1961;108(6):972. doi:10.1001/archinte.1961.03620120156039

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The appearance of a short book discussing the principles of drug metabolism would ordinarily be greatly welcomed by those wishing to acquaint themselves with this area of research, and the book would be most valuable as a text in a course on this subject. Unfortunately the present book has a number of deficiencies which greatly limit its value. The major objection this reviewer had was the rather superficial coverage of those sections of the book which, judging from the book title, should be the most important. Thus the chapter on metabolic transformation of drugs consists of brief outlines of the routes of biotransformation of a few drugs, while the sections on glucuronic acid and β-glucuronidase are disproportionately long and are concerned chiefly not with the fate of drugs but with biochemical and physiological aspects of glucuronic acid and glucuronidase. There are a number of relatively minor errors, such as formulas

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