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April 1962

The Etiology of Leukemia: Recent Developments in the Studies of a Mouse Leukemia Virus

Author Affiliations

Cancer Research Unit Veterans Administration Hospital Bronx, N.Y.

Arch Intern Med. 1962;109(4):375-378. doi:10.1001/archinte.1962.03620160001001

The nature of human leukemia is still obscure; no direct and convincing evidence is yet available to prove experimentally that leukemia in humans is of viral origin. And yet, results of experiments performed during the past decade on mouse leukemia, in addition to previous experimental studies performed on chicken leukosis, strongly suggest that leukemia and allied diseases in other species also, including humans, may be of viral origin.1 The various forms of leukemia developing in mice and in man are so similar in their clinical course, and morphology, that it would be quite difficult to assume that leukemia in humans is a disease fundamentally different from that observed in mice.

In a large and mixed population of mice, the incidence of leukemia is, in general, low. In this respect it is not unlike the generally low incidence of leukemia in man. However, families of mice having a higher incidence

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