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April 1962

Serum Enzyme Activities Following MorphineA Study of Transaminase and Alkaline Phosphatase Levels in Normal Persons and Those with Gallbladder Disease

Arch Intern Med. 1962;109(4):429-437. doi:10.1001/archinte.1962.03620160055008

An increase of serum glutamic oxalacetic transaminase (SGO-T) activity following myocardial infarction was first described by LaDue et al.1 and subsequently confirmed by numerous investigators.2-6 Much emphasis has been placed on elevated SGO-T values in substantiating the clinical impression of myocardial infarction, especially when the electrocardiogram reveals equivocal changes, previous infarction, left bundle branch block, or arrhythmia.7-9 With increased understanding of the ubiquitous nature of GO-T distribution in human tissues, it has become apparent that liver necrosis10-14 and a host of other disease states5,6,15-21 can provoke a rise in SGO-T activity. Thus, confusion may still exist when there is elevated SGO-T activity in the absence of electrocardiographic evidence of heart muscle damage.

Obstructive biliary tract disease causes a rise in SGO-T activity,22,23 and this rise may be unrelated to hepatic necrosis.24 The demonstration of high GO-T activity in bile25 further serves to