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June 1962

Uremia: The Biochemistry, Pathogenesis and Treatment

Arch Intern Med. 1962;109(6):765-766. doi:10.1001/archinte.1962.03620180127016

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


For years the whole problem of uremia has baffled clinicians. The chemistry, cause, and treatment have been interesting but confusing, and the great mass of literature has not served to clarify this clinical puzzle. The authors are to be congratulated on taking a frontal assault on this problem and very lucidly organizing all available information. They have drawn heavily from their own experiences between 1952 and 1959, during which time they were able to study, not just observe, 366 patients with uremia. To supplement their own material and observations they have comprehensively reviewed the world literature, listing 1,279 references. The value of this book is further enhanced as a reference work by the excellent author and subject index.

The book is divided into five sections: first, an introduction with a description of what is uremia and what is not uremia, together with a history of hemodialysis and the search for

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