Severe infections due to the Pseudomonas aeruginosa organism were rare before the use of antibiotics1 and usually occurred in debilitated patients or following instrumentation of the urinary tract.2,3 Since penicillin and broad-spectrum antibiotics have been introduced, there have been reports that the Pseudomonas organism has emerged to produce serious infections.4-6 These infections are difficult to treat because the organism is resistant to most antibiotics. Sensitivity to polymyxin B sulfate, neomycin sulfate, and streptomycin has been reported, but resistance to the latter 2 develops rapidly.7-9 Even though in vitro sensitivity to polymyxin B sulfate can be demonstrated, eradication of the organism from a fresh blood clot has been unsuccessful.8
Twenty-four cases of endocarditis due to Pseudomonas aeruginosa have been reported.2,10-17 Seven of these developed after surgery for either acquired or congenital heart disease. Six of these 7 cases died. One recovered after removal of a
SYKES C, BECKWITH JR, MULLER WH, WOOD JE. Postoperative Endoauriculitis Due to Pseudomonas Aeruginosa Cured by a Second Operation. Arch Intern Med. 1962;110(1):113–116. doi:10.1001/archinte.1962.03620190115018
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.