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August 1962

Low-Fat Diet in Familial Mediterranean Fever: A Therapeutic Trial

Author Affiliations


Department of Medicine, Tel-Hashomer Hospital.

Arch Intern Med. 1962;110(2):150-154. doi:10.1001/archinte.1962.03620200010003

Familial Mediterranean fever (FMF) is a genetic disorder with complete autosomal recessive inheritance. It is prevalent in peoples of Mediterranean stock, particularly Sephardi Jews and Armenians.1,2 The disease is manifested by 2 independent phenotypic characters due to the same presumed inborn error of metabolism: (1) attacks of fever accompanied by pain in the abdomen, chest, skin or joints, usually appearing in childhood or adolescence and recurring at irregular intervals throughout life; (2) amyloidosis, causing death, at an early age, due to renal failure.3

The only factor which is known to have produced remission from attacks with a high degree of consistency is pregnancy.1 Since no uniformly successful therapeutic measure has been made available to date, the report of Mellinkoff et al.4 as to the efficacy of low-fat diet in 8 cases is of special interest. A therapeutic trial in a large series of cases was embarked

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