The coexistence of Addison's disease and thyrotoxicosis in the same individual is a medical rarity. Critical review of the literature reveals only 12 adequately documented instances1-11 of this association. Chronologic study of these cases mirrors the steady increase in our understanding of endocrine diseases at the bedside and the development of newer techniques in the laboratory.
The first 4 reported cases1-4 were all rapidly fatal, and the diagnosis of adrenocortical atrophy and thyroid hyperplasia was made at autopsy in 3 of them.1,3,4 The first successfully treated case was reported by Perera and Parker.5 All subsequently reported cases were treated successfully except for one of the 2 adequately documented cases reported by Houston and Price (Case 3).6 Two patients4,8 had developed diabetes mellitus less than 5 years before the onset of thyrotoxicosis; they developed Addison's disease subsequently. Another patient11 developed mild thyrotoxicosis 3
BRUNO MS, OBER WB, KUPPERMAN HS, EPSTEIN JA. Coexistent Addison's Disease and Thyrotoxicosis. Arch Intern Med. 1962;110(2):155–161. doi:10.1001/archinte.1962.03620200015004
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