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August 1962

The Sézary Syndrome: A Unique Cutaneous Reticulosis

Author Affiliations


Resident in Medicine, Veterans Administration Hospital (Dr. Cypress).; U.S. Public Health Service Research Fellow in Hematology (Drs. Kimball and McKenzie).; From the Departments of Medicine, the Veterans Administration Hospital, and the University of Miami School of Medicine.; Assistant Professor of Medicine, University of Miami School of Medicine, and Chief, Hematology Section, Veterans Administration Hospital (Dr. Brody).

Arch Intern Med. 1962;110(2):205-210. doi:10.1001/archinte.1962.03620200065012

The purpose of this report is to describe a patient with a cutaneous reticulosis, the Sézary syndrome,1-6 which is characterized by an intense, pruritic, generalized exfoliative dermatitis accompanied by cutaneous and peripheral blood infiltration with mononuclear lymphoid cells possessing particular staining properties. The unusual nature of this disease, its infrequent occurrence, and the fact that disorders of the skin and blood-forming organs, both individually and in combination, must be considered in a prolonged and difficult differential diagnosis stimulated singular interest in this patient. There have been only 16 previously recorded cases of this syndrome.7

Report of a Case  A 71-year-old white male was admitted to the Coral Gables Veterans Administration Hospital for the second time on Dec. 27, 1960, because of a diffuse skin eruption of 7 months' duration. The patient was first admitted to this hospital in April, 1960, with a febrile respiratory infection. This was self-limited