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Sept 1962

Histoplasma Endocarditis: Report on a Patient Treated with Amphotericin B, with Review of Amphotericin B Therapy for Histoplasmosis

Author Affiliations


Fellow in Medicine (Dr. Palmer); Section of Medicine (Dr. Geraci); Fellow in Pathology (Dr. Thomas); Mayo Clinic and Mayo Foundation.

Arch Intern Med. 1962;110(3):359-365. doi:10.1001/archinte.1962.03620210083015

The primary purposes of this paper are: (1) to report a case of progressive, fatal histoplasmosis treated with amphotericin B in which the predominant lesion was that of vegetative endocarditis, (2) to discuss briefly the clinical entity of histoplasmosis with particular reference to endocardial involvement, and (3) to review amphotericin B therapy for histoplasmosis and Histoplasma endocarditis. One other case of Histoplasma endocarditis found at the Mayo Clinic was that reported by Broders and associates in 1943.6

Clinical Features of Histoplasmosis  Histoplasmosis infects various organ systems, but particularly the respiratory and gastrointestinal tracts. Lesions of the throat and nasopharynx are often present. Productive cough, loss of weight, anemia, leukopenia, sweats, fatigue, chest pain, fever, and chills were listed as the chief clinical manifestations by Vivian and associates reporting on 20 cases seen at the Mayo Clinic.24 Hepatosplenomegaly was a frequent finding.The most common type of the disease

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